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Mst1rtm1.1Sew
Targeted Allele Detail
Summary
Symbol: Mst1rtm1.1Sew
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase); targeted mutation 1.1, Susan E Waltz
MGI ID: MGI:2386421
Synonyms: RON -, TK-
Gene: Mst1r  Location: Chr9:107784072-107797582 bp, + strand  Genetic Position: Chr9, 59.07 cM, cytoband F1
Alliance: Mst1rtm1.1Sew page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75503
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 13 through 18 were excised by the in vitro expression of cre recombinase. The deleted region encodes the tyrosine kinase domain which is essential for catalytic activity. (J:75503)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Mst1rtm1.1Sew
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mst1r Mutation:  61 strains or lines available
References
Original:  J:75503 Waltz SE, et al., Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses. J Clin Invest. 2001 Aug;108(4):567-76
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory