Foxa1^tm1(cre)Sew
Targeted Allele Detail

Summary

• Symbol: Foxa1^tm1(cre)Sew
• Name: forkhead box A1; targeted mutation 1, Susan E Waltz
• MGI ID: MGI:2386437
• Gene: Foxa1 Location: Chr12:57587414-57593702 bp, - strand Genetic Position: Chr12, 24.7 cM
• Alliance: Foxa1^tm1(cre)Sew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75503
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Foxa1^tm1(cre)Sew expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxa1 (MGI:1347472)

• Mutation details: The majority of exon 2 was replaced with a cassette containing NLS-cre. While the endogenous promoter is active from E8-8.5 through adulthood in endoderm derived tissues, namely, the lung, liver, and gastrointestinal tract, the expression of the targeted allele was ubiquitous. (J:75503)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxa1 (mouse) Summary of all recombinase alleles driven by Foxa1. Alliance mouse Foxa1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxa1 Mutation: 21 strains or lines available

References

• Original: J:75503 Waltz SE, et al., Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses. J Clin Invest. 2001 Aug;108(4):567-76
• All: 2 reference(s)