Wrn^tm1Lgu
Targeted Allele Detail

Summary

• Symbol: Wrn^tm1Lgu
• Name: Werner syndrome RecQ like helicase; targeted mutation 1, Leonard Guarente
• MGI ID: MGI:2386438
• Synonyms: WRN-
• Gene: Wrn Location: Chr8:33724412-33875555 bp, - strand Genetic Position: Chr8, 20.3 cM, cytoband A4
• Alliance: Wrn^tm1Lgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61567
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3'-most exon encoding part of the catalytic helicase domain was replaced with a beta-geo cassette via homologous recombination. The null allele was confirmed by Western blot analysis of ear fibroblasts derived from homozygous mutant animals. No protein product was detected using antibodies directed against the N- and C-terminal regions of Wrn. (J:61567)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wrn Mutation: 94 strains or lines available

References

• Original: J:61567 Lombard DB, et al., Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol. 2000 May;20(9):3286-91
• All: 10 reference(s)