Arc^tm1Amt
Targeted Allele Detail

Summary

• Symbol: Arc^tm1Amt
• Name: activity regulated cytoskeletal-associated protein; targeted mutation 1, Andrew Matus
• MGI ID: MGI:2386454
• Gene: Arc Location: Chr15:74540932-74544419 bp, - strand Genetic Position: Chr15, 34.25 cM
• Alliance: Arc^tm1Amt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61449
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the gene was deleted by replacement of a 2.2 kb region containing the 5' untranslated region and 634 bp of coding sequences with a neomycin resistance cassette via homologous recombination. Homozygous mutant embryos were observed by PCR genotype analysis up to day E9.5. In situ hybridization did not detect gene expression in homozygous mutant embryos. (J:61449)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arc Mutation: 29 strains or lines available

References

• Original: J:61449 Liu D, et al., Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis. Mech Dev. 2000 Apr;92(2):207-15
• All: 1 reference(s)