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Arctm1Amt
Targeted Allele Detail
Summary
Symbol: Arctm1Amt
Name: activity regulated cytoskeletal-associated protein; targeted mutation 1, Andrew Matus
MGI ID: MGI:2386454
Gene: Arc  Location: Chr15:74540932-74544419 bp, - strand  Genetic Position: Chr15, 34.25 cM
Alliance: Arctm1Amt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61449
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of the gene was deleted by replacement of a 2.2 kb region containing the 5' untranslated region and 634 bp of coding sequences with a neomycin resistance cassette via homologous recombination. Homozygous mutant embryos were observed by PCR genotype analysis up to day E9.5. In situ hybridization did not detect gene expression in homozygous mutant embryos. (J:61449)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arc Mutation:  28 strains or lines available
References
Original:  J:61449 Liu D, et al., Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis. Mech Dev. 2000 Apr;92(2):207-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory