About   Help   FAQ
Ath16C57BL/6J
QTL Variant Detail
Summary
QTL variant: Ath16C57BL/6J
Name: atherosclerosis 16; C57BL/6J
MGI ID: MGI:2386549
QTL: Ath16  Location: Chr19:42426917-42427005 bp  Genetic Position: Chr19, cM position of peak correlated region/allele: 33.03 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased aortic lesion size compared to FVB/NCr.
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76127

Two independent strain intercosses that carry atherosclerosis phenotype-sensitizing Apoe deficiency were performed to reveal artherosclerosis susceptibility loci that are distinct from loci linked to lipoprotein levels.

Animals from a C57BL/6J-derived background are susceptible to atherosclerosis and yield several-fold higher aortic lesion scores compared to animals from an FVB/NCr-derived background.

In the first cross, referred to as cross 1, B6.129P2-Apoetm1Unc x FVB.129P2-Apoetm1Bres F1 mice were crossed and the F1 offspring were intercrossed to create 197 (B6.129P2-Apoetm1Unc x FVB.129P2-Apoetm1Bres) F2 mice for the QTL analysis. Interval mapping was done with 194 markers at a distance of no more than 10cM.

In the second, confirmatory cross, B6.129P2-Apoetm1Unc x FVB.129P2-Apoetm1Bres F1 mice were crossed and the F1 offspring were intercrossed to create 186 (B6.129P2-Apoetm1Unc x FVB.129P2-Apoetm1Bres)F2 mice for QTL analysis. This cross was referred to as cross 2; these mice were genotyped using 127 markers at no more than 10cM intervals.

A QTL observed on Chr 19 in cross 1 but not in cross 2 has been named Ath16. Single marker and interval mapping revealed a peak at D19Mit120 (LOD 3.8 in male F2 mice, no linkage was found in female mice on chromosome 19). FVB/NCr-derived alleles confer increased lesion size in a dominant manner at this locus.

Ath16 is evolutionarily conserved with human chromosomal regions 9q12-21, 9q24 and 10q23-26. Possible candidate genes for Ath16 areVldlr, Fgf8, Csf2ra, and Prdx3.

References
Original:  J:76127 Dansky HM, et al., A phenotype-sensitizing apoe-deficient genetic background reveals novel atherosclerosis predisposition Loci in the mouse. Genetics. 2002 Apr;160(4):1599-608
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory