Vcam1^tm2Flv
Targeted Allele Detail

Summary

• Symbol: Vcam1^tm2Flv
• Name: vascular cell adhesion molecule 1; targeted mutation 2, Richard A Flavell
• MGI ID: MGI:2386556
• Synonyms: vcam-1^flox
• Gene: Vcam1 Location: Chr3:115903669-115923337 bp, - strand Genetic Position: Chr3, 50.17 cM
• Alliance: Vcam1^tm2Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68147
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The cytokine responsive promoter region and exon 1 were left flanked by single loxP site after a floxed neo cassette was excised by in vivo expression of cre recombinase. Normal protein levels were detected in homozygous mutant mice by analysis of dendritic cells obtained from the spleen. (J:68147)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vcam1 Mutation: 44 strains or lines available

References

• Original: J:68147 Koni PA, et al., Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice. Impaired lymphocyte migration to bone marrow. J Exp Med. 2001 Mar 19;193(6):741-54
• All: 19 reference(s)