Pbw2^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Pbw2^DBA/2J
• Name: pentobarbital withdrawal QTL 2; DBA/2J
• MGI ID: MGI:2386561
• QTL: Pbw2 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased pentobarbital withdrawal severity compared to C57BL/6J. (J:76251)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76251

Pbw2, a QTL previously reported with suggestive linkage to pentobarbital (PB) withdrawal, was confirmed using the short DNA segment (SDS) strain D2.B6-Mpdz. The D2.B6-Mpdz strain carries a short C57BL/6J-derived region from D4Mit80 (37.7 cM) - Mpdz (38.6cM) on a DBA/2J genetic background. Parental strain DBA/2J exhibits severe PB withdrawal symptoms compared to donor strain C57BL/6J. D2.B6-Mpdz animals exhibit significantly less severe PB withdrawal compared to DBA/2J animals (LOD=5.6) thus confirming the existence of Pbw2. Pbw2 maps to the same <1 cM interval as Alcw2 and may be controlled by the same gene(s). Mpdz, a strong candidate gene for Alcw2, is also a viable candidate gene for Pbw2.

References

• Original: J:76251 Fehr C, et al., Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. J Neurosci. 2002 May 1;22(9):3730-8
• All: 2 reference(s)