H2az2^{Tg(Wnt1-cre)11Rth}
Transgenic Allele Detail

Summary

• Symbol: H2az2^{Tg(Wnt1-cre)11Rth}
• Name: H2A.Z histone variant 2; transgene insertion 11, David H Rowitch
• MGI ID: MGI:2386570
• Synonyms: Tg(Wnt1-cre)11Rth, Wnt1-Cre, Wnt1^Cre, Wnt1cre, Wnt1::Cre
• Gene: H2az2 Location: Chr11:6377229-6394443 bp, - strand Genetic Position: Chr11, 4.01 cM
• Alliance: H2az2^{Tg(Wnt1-cre)11Rth} page

Evidence of inflammation in both the proximal and mid-colon of the Ednrb^tm1Nrd/Ednrb^tm1Nrd Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/0 animals

Show the 19 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1/J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutations: Insertion, Intragenic deletion
• H2az2^{Tg(Wnt1-cre)11Rth} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Wnt1

• Mutation details: The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. Line 11 inserted into the gene at 6425500-6456783 (Build GRCm38/mm10) resulting in a 31,283 bp deletion. Founder line x has a copy number of greater than 5. (J:69326)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Wnt1 (species not specified) Summary of all recombinase alleles driven by Wnt1. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

1078 assay results 44 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying H2az2^{Tg(Wnt1-cre)11Rth}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any H2az2 Mutation: 26 strains or lines available

Notes

Homozygous transgenic mice that are also homozygous for Tg(Wnt1-GAL4)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References

• Original: J:69326 Danielian PS, et al., Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol. 1998 Dec 3;8(24):1323-6
• All: 824 reference(s)