Pax5^tm3Mbu
Targeted Allele Detail

Summary

• Symbol: Pax5^tm3Mbu
• Name: paired box 5; targeted mutation 3, Meinrad Busslinger
• MGI ID: MGI:2386577
• Synonyms: Pax5^F
• Gene: Pax5 Location: Chr4:44524757-44710487 bp, - strand Genetic Position: Chr4, 23.55 cM
• Alliance: Pax5^tm3Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75504
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:75504)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pax5^tm3Mbu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax5 Mutation: 37 strains or lines available

References

• Original: J:75504 Horcher M, et al., Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity. 2001 Jun;14(6):779-90
• All: 11 reference(s)