Fembrs1^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Fembrs1^MRL/MpJ
• Name: femur breaking strength 1; MRL/MpJ
• MGI ID: MGI:2386580
• QTL: Fembrs1 Location: Chr2:117942930-117943090 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 59.34 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased bone strength compared to SJL/J. (J:76508)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76508

119 polymorphic markers were screened in 633 (MRL/MpJ x SJL/J)F2 female animals to detect loci associated with femur breaking strength. 7-week old female animals were used for the study. Fembrs1 was identified on mouse Chromosome 2 with LOD = 3.6 at D2Mit62. MRL/MpJ-derived alleles confer increased bone strength with dominant inheritance at Fembrs1.

References

• Original: J:76508 Li X, et al., Genetic Dissection of Femur Breaking Strength in a Large Population (MRL/MpJxSJL/J) of F2 Mice: Single QTL Effects, Epistasis, and Pleiotropy. Genomics. 2002 May;79(5):734-40
• All: 2 reference(s)