Fembrs3^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Fembrs3^MRL/MpJ
• Name: femur breaking strength 3; MRL/MpJ
• MGI ID: MGI:2386586
• QTL: Fembrs3 Location: Chr10:92338568-92338767 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 47.06 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased bone strength compared to SJL/J. (J:76508)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76508

119 polymorphic markers were screened in 633 (MRL/MpJ x SJL/J)F2 female animals to detect loci associated with femur breaking strength. 7-week old female animals were used for the study. Fembrs3 was identified on mouse Chromosome 10 with LOD=2.7 at D10Mit95. MRL/MpJ-derived alleles confer increased bone strength with dominant inheritance at Fembrs3.

References

• Original: J:76508 Li X, et al., Genetic Dissection of Femur Breaking Strength in a Large Population (MRL/MpJxSJL/J) of F2 Mice: Single QTL Effects, Epistasis, and Pleiotropy. Genomics. 2002 May;79(5):734-40
• All: 1 reference(s)