Npr1^tm1Kuhn
Targeted Allele Detail

Summary

• Symbol: Npr1^tm1Kuhn
• Name: natriuretic peptide receptor 1; targeted mutation 1, Michaela Kuhn
• MGI ID: MGI:2386604
• Synonyms: floxed GC-A, GC-A^3lox
• Gene: Npr1 Location: Chr3:90357898-90373173 bp, - strand Genetic Position: Chr3, 39.23 cM
• Alliance: Npr1^tm1Kuhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76460
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1, which contains the translational start codon, was flanked by an upstream floxed neo cassette and a downstream single loxP site. Quantitative RT-PCR of RNA obtained from aorta and pulmonary artery tissue showed normal levels of transcript in homozygous mutant mice. (J:76460)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr1 Mutation: 60 strains or lines available

References

• Original: J:76460 Holtwick R, et al., Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7142-7
• All: 22 reference(s)