Tg(Col2a1-cre)1Rsjo
Transgene Detail

Summary

• Symbol: Tg(Col2a1-cre)1Rsjo
• Name: transgene insertion 1, Randall S Johnson
• MGI ID: MGI:2386649
• Synonyms: colIIcre
• Transgene: Tg(Col2a1-cre)1Rsjo Location: unknown
• Alliance: Tg(Col2a1-cre)1Rsjo page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Col2a1-cre)1Rsjo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Col2a1 (25412)

  Col2a1

  (MGI:88452)

• Mutation details: The cre coding region along with a nuclear localization and polyadenylation signals was adjoined to the rat collagen 2a1 promoter and enhancer. The rat Col2a promoter was shown to drive expression in cartilage. (J:72709)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col2a1 (rat) Summary of all recombinase alleles driven by Col2a1. Comparative matrix view of recombinase activities Alliance rat Col2a1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:72709 Schipani E, et al., Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 2001 Nov 1;15(21):2865-76
• All: 11 reference(s)