Gckr^tm1Jfg
Targeted Allele Detail

Summary

• Symbol: Gckr^tm1Jfg
• Name: glucokinase regulatory protein; targeted mutation 1, Joseph F Grippo
• MGI ID: MGI:2386670
• Synonyms: GKRP(-)
• Gene: Gckr Location: Chr5:31454787-31484658 bp, + strand Genetic Position: Chr5, 17.27 cM
• Alliance: Gckr^tm1Jfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61183
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exons 4 and 5 were replaced by a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis. Western blot and immunhistochemical analyses verified the absence of protein. (J:61183)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gckr Mutation: 42 strains or lines available

References

• Original: J:61183 Grimsby J, et al., Characterization of glucokinase regulatory protein-deficient mice. J Biol Chem. 2000 Mar 17;275(11):7826-31
• All: 1 reference(s)