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Inhbatm2Zuk
Targeted Allele Detail
Summary
Symbol: Inhbatm2Zuk
Name: inhibin beta-A; targeted mutation 2, Martin M Matzuk
MGI ID: MGI:2386671
Synonyms: InhbaBK
Gene: Inhba  Location: Chr13:16186436-16206206 bp, + strand  Genetic Position: Chr13, 5.85 cM
Alliance: Inhbatm2Zuk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63882
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of exon 2 was replaced with the mature domain of Inhbb and a neomycin resistance cassette was inserted into the downstream intron via homologous recombination. In situ hybridization, RNase protection assay, and Western blot verified the absence of Inhba expression in homozygous mutant animals. (J:63882)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Inhba Mutation:  31 strains or lines available
References
Original:  J:63882 Brown CW, et al., Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet. 2000 Aug;25(4):453-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory