Inhba^tm2Zuk
Targeted Allele Detail

Summary

• Symbol: Inhba^tm2Zuk
• Name: inhibin beta-A; targeted mutation 2, Martin M Matzuk
• MGI ID: MGI:2386671
• Synonyms: Inhba^BK
• Gene: Inhba Location: Chr13:16186436-16206206 bp, + strand Genetic Position: Chr13, 5.85 cM
• Alliance: Inhba^tm2Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63882
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 was replaced with the mature domain of Inhbb and a neomycin resistance cassette was inserted into the downstream intron via homologous recombination. In situ hybridization, RNase protection assay, and Western blot verified the absence of Inhba expression in homozygous mutant animals. (J:63882)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Inhba Mutation: 31 strains or lines available

References

• Original: J:63882 Brown CW, et al., Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet. 2000 Aug;25(4):453-7
• All: 6 reference(s)