Blnk^tm1Kplm
Targeted Allele Detail

Summary

• Symbol: Blnk^tm1Kplm
• Name: B cell linker; targeted mutation 1, Kong-Peng Lam
• MGI ID: MGI:2386672
• Synonyms: BLNK^-, SLP-65^-
• Gene: Blnk Location: Chr19:40917371-40982664 bp, - strand Genetic Position: Chr19, 34.26 cM
• Alliance: Blnk^tm1Kplm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61130
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon and 4.5 kb of upstream sequence were replaced by a neomycin selection cassette. Expression was undetected in homozygous mutant mice by RT-PCR analysis of bone marrow and spleen samples. (J:61130)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Blnk Mutation: 78 strains or lines available

References

• Original: J:61130 Xu S, et al., B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int Immunol. 2000 Mar;12(3):397-404
• All: 5 reference(s)