Il1rl1^tm1Anjm
Targeted Allele Detail

Summary

• Symbol: Il1rl1^tm1Anjm
• Name: interleukin 1 receptor-like 1; targeted mutation 1, Andrew NJ McKenzie
• MGI ID: MGI:2386675
• Synonyms: ST2^-, T1/ST2^-
• Gene: Il1rl1 Location: Chr1:40468730-40504575 bp, + strand Genetic Position: Chr1, 19.19 cM
• Alliance: Il1rl1^tm1Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61108
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exons 4 and 5 were replaced by a neomycin selection cassette inserted at the endogenous locus via homologous recombination. The deleted region encoded a portion of the extracellular domain which is common to both membrane bound and soluble forms of the protein. RT-PCR analysis of activated lymphocytes showed an absence of normal transcript in homozygous mutant mice. Cell surface expression of the encoded protien was undetected by flow cytometric analysis of cultured mast cells. (J:61108)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il1rl1 Mutation: 59 strains or lines available

References

• Original: J:61108 Townsend MJ, et al., T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses. J Exp Med. 2000 Mar 20;191(6):1069-76
• All: 166 reference(s)