Abcc8^tm1Jbry
Targeted Allele Detail

Summary

• Symbol: Abcc8^tm1Jbry
• Name: ATP-binding cassette, sub-family C member 8; targeted mutation 1, Joseph Bryan
• MGI ID: MGI:2386677
• Synonyms: Sur1^-, Sur1KO
• Gene: Abcc8 Location: Chr7:45753952-45829441 bp, - strand Genetic Position: Chr7, 29.66 cM
• Alliance: Abcc8^tm1Jbry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61356
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 2 with a puromycin resistance cassette via homologous recombination. Photolabeling of neuronal membranes from homozygous mutant animals did not detect protein product. (J:61356)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcc8 Mutation: 78 strains or lines available

References

• Original: J:61356 Seghers V, et al., Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion. J Biol Chem. 2000 Mar 31;275(13):9270-7
• All: 32 reference(s)