Sharpin^cpdm-Dem
Spontaneous Allele Detail

Summary

• Symbol: Sharpin^cpdm-Dem
• Name: SHANK-associated RH domain interacting protein; chronic proliferative dermatitis, Peter Demant
• MGI ID: MGI:2386682
• Synonyms: cpdm^Dem
• Gene: Sharpin Location: Chr15:76231240-76235310 bp, - strand Genetic Position: Chr15, 35.75 cM
• Alliance: Sharpin^cpdm-Dem page

Mutation origin

• Strain of Origin: OcB3/Dem

Mutation description

• Allele Type: Spontaneous
• Mutations: Intragenic deletion, Single point mutation
• Mutation details: This allele comprises a C-to-A transition at coding nucleotide 15 near the 5' end of exon 1 (a silent mutation that doesn't change the alanine codon at position 5), followed by a 14 bp deletion of coding nucleotides 19-32. The deletion disrupts the reading frame resulting in a premature stop codon. (J:121810)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sharpin Mutation: 25 strains or lines available

References

• Original: J:68129 Sundberg JP, et al., The chronic proliferative dermatitis mouse mutation (cpdm): mapping of the mutant gene locus. J Exp Anim Sci. 2000;41:101-8
• All: 4 reference(s)