Ppard^tm1.1Rev
Targeted Allele Detail

Summary

• Symbol: Ppard^tm1.1Rev
• Name: peroxisome proliferator activator receptor delta; targeted mutation 1.1, Ronald M Evans
• MGI ID: MGI:2386684
• Synonyms: Ppardelta^-
• Gene: Ppard Location: Chr17:28451715-28520446 bp, + strand Genetic Position: Chr17, 14.64 cM
• Alliance: Ppard^tm1.1Rev page

Pathologies of Ppard^tm1.1Rev/Ppard^tm1.1Rev mouse placentas

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73557
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4, which encodes the amino terminal portion of the DNA binding domain was excised along with a downstream neo cassette via the expression of cre recombinase in vitro. (J:73557)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppard Mutation: 68 strains or lines available

References

• Original: J:73557 Barak Y, et al., Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):303-8
• All: 12 reference(s)