Pdha1^tm1.1Ptl
Targeted Allele Detail

Summary

• Symbol: Pdha1^tm1.1Ptl
• Name: pyruvate dehydrogenase E1 alpha 1; targeted mutation 1.1, Mulchand S Patel
• MGI ID: MGI:2386704
• Synonyms: Pdha1^{delta ex8}
• Gene: Pdha1 Location: ChrX:158905205-158921409 bp, - strand Genetic Position: ChrX, 73.95 cM, cytoband F3-F4
• Alliance: Pdha1^tm1.1Ptl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74192
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed region of Pdha1^tm1Ptl containing exon 8 was excised by the expression of cre recombinase in vivo. Studies of an ES cell line recombined in vitro showed highly reduced levels of endogenous protein as well as a near ablation of pyruvate dehydrogenase activity. (J:74192)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdha1 Mutation: 24 strains or lines available

References

• Original: J:74192 Johnson MT, et al., Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development. Mol Genet Metab. 2001 Nov;74(3):293-302
• All: 2 reference(s)