Mafk^tm1Jeng
Targeted Allele Detail

Summary

• Symbol: Mafk^tm1Jeng
• Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian); targeted mutation 1, James Douglas Engel
• MGI ID: MGI:2386716
• Synonyms: mafK-
• Gene: Mafk Location: Chr5:139777291-139788409 bp, + strand Genetic Position: Chr5, 78.81 cM
• Alliance: Mafk^tm1Jeng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78982
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 and all of exon 3 were replaced by a cassette inserted downstream of the translational start codon and containing lacZ and floxed neo genes. RNAse protection assays were utilized to confirm the absence of transcript in homozygous mutant mice. Expression of beta-galactosidase was driven by the endogenous promoter. (J:78982)

Expression

In Mice Carrying this Mutation:

66 assay results 3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mafk Mutation: 14 strains or lines available

References

• Original: J:78982 Shavit JA, et al., Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. Genes Dev. 1998 Jul 15;12(14):2164-74
• All: 10 reference(s)