Tcsz3^LG/J
QTL Variant Detail

Summary

• QTL variant: Tcsz3^LG/J
• Name: tooth central size 3; LG/J
• MGI ID: MGI:2386734
• QTL: Tcsz3 Location: unknown Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: LG/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased tooth size compared to SM/J. (J:76126)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Tcsz3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76126

76 polymorphic microsatellite markers at an average distance of 27.5 cM were screened in 535 (SM/J x LG/J)F2 animals to identify QTLs associated with tooth development. Parental inbred strain LG/J exhibits larger body size compared to SM/J. A QTL affecting tooth size, Tcsz3, mapped to mouse Chromosome 14 from 22.5 cM - 44.5 cM. Tcsz3 exceeds the P<0.001 significance threshold of LOD=4.004. LG/J-derived alleles confer increased tooth size in an additive fashion at Tcsz3.

References

• Original: J:76126 Workman MS, et al., Analysis of quantitative trait locus effects on the size and shape of mandibular molars in mice. Genetics. 2002 Apr;160(4):1573-86
• All: 1 reference(s)