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Tcsz3SM/J
QTL Variant Detail
Summary
QTL variant: Tcsz3SM/J
Name: tooth central size 3; SM/J
MGI ID: MGI:2386735
QTL: Tcsz3  Location: unknown  Genetic Position: Chr14, Syntenic
Variant
origin
Strain of Specimen:  SM/J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased tooth size. (J:76126)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76126

76 polymorphic microsatellite markers at an average distance of 27.5 cM were screened in 535 (SM/J x LG/J)F2 animals to identify QTLs associated with tooth development. Parental inbred strain LG/J exhibits larger body size compared to SM/J. A QTL affecting tooth size, Tcsz3, mapped to mouse Chromosome 14 from 22.5 cM - 44.5 cM. Tcsz3 exceeds the P<0.001 significance threshold of LOD=4.004. LG/J-derived alleles confer increased tooth size in an additive fashion at Tcsz3.

References
Original:  J:76126 Workman MS, et al., Analysis of quantitative trait locus effects on the size and shape of mandibular molars in mice. Genetics. 2002 Apr;160(4):1573-86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory