Stat6^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Stat6^tm1Jni
• Name: signal transducer and activator of transcription 6; targeted mutation 1, James N Ihle
• MGI ID: MGI:2386745
• Synonyms: Stat6^-
• Gene: Stat6 Location: Chr10:127478855-127496826 bp, + strand Genetic Position: Chr10, 74.59 cM
• Alliance: Stat6^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32607
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The first coding exon was replaced with a neomycin resistance gene via homologous recombination. Immunoprecipitation and Western blot analysis using an antibody directed against the C-terminus of the protein did not detect wild-type gene product in homozygous mutant animals. However, a smaller protein was detected at low levels, possibly produced from residual transcripts. Il4-induced DNA-binding activity of Stat6 was not present in homozygous mutant animals. (J:32607)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat6 Mutation: 53 strains or lines available

References

• Original: J:32607 Shimoda K, et al., Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 1996 Apr 18;380(6575):630-3
• All: 37 reference(s)