Stat6^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Stat6^tm1Aki
• Name: signal transducer and activator of transcription 6; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2386746
• Synonyms: Stat6-, STAT6KO
• Gene: Stat6 Location: Chr10:127478855-127496826 bp, + strand Genetic Position: Chr10, 74.59 cM
• Alliance: Stat6^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32561
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3 exons encoding the SH2 domain were replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis of splenocytes from homozygous mutant animals using a probe to exons downstream of the deleted region did not detect gene expression. (J:32561)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Stat6 Mutation: 53 strains or lines available

References

• Original: J:32561 Takeda K, et al., Essential role of Stat6 in IL-4 signalling. Nature. 1996 Apr 18;380(6575):627-30
• All: 67 reference(s)