Esr1^tm1.1Mma
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1.1Mma
• Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Manuel Mark
• MGI ID: MGI:2386760
• Synonyms: ERalpha^-, ERalphaKO, ERalpha^L-
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1.1Mma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64426
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The mutation is a derivative of Esr1^tm1Mma. The floxed exon 3 and TK-neo cassette were deleted by mating Esr1^tm1 animals to a cre-expressing line. Absence of gene expression was confirmed by Western blot and RT-PCR analysis of uterus protein and RNA from homozygous mutant animals. (J:64426, J:206373)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:64426 Dupont S, et al., Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development. 2000 Oct;127(19):4277-91
• All: 105 reference(s)