Esr2tm1Mma
Targeted Allele Detail
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Symbol: |
Esr2tm1Mma |
Name: |
estrogen receptor 2 (beta); targeted mutation 1, Manuel Mark |
MGI ID: |
MGI:2386761 |
Synonyms: |
BERKO, ERbeta- |
Gene: |
Esr2 Location: Chr12:76167193-76224033 bp, - strand Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
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Alliance: |
Esr2tm1Mma page
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Germline Transmission: |
Earliest citation of germline transmission:
J:64426
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Parent Cell Line: |
H1 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 3 encoding the first zinc finger domain via homologous recombination. RT-PCR analysis of ovary mRNA from mutant animals detected 3 faint RNA species all lacking exon 3. Immunohistochemical analysis of ovary sections from homozygous mutant animals did not detect protein product.
(J:64426)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Esr2 Mutation: |
36 strains or lines available
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Original: |
J:64426 Dupont S, et al., Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development. 2000 Oct;127(19):4277-91 |
All: |
37 reference(s) |
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