Gata4^tm1.1Sho
Targeted Allele Detail

Summary

• Symbol: Gata4^tm1.1Sho
• Name: GATA binding protein 4; targeted mutation 1.1, Stuart Orkin
• MGI ID: MGI:2386766
• Gene: Gata4 Location: Chr14:63436371-63509141 bp, - strand Genetic Position: Chr14, 33.24 cM
• Alliance: Gata4^tm1.1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77392
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: In vivo expression of cre recombinase resulted in the excision of an intronic floxed neo cassette from Gata4^tm1Sho. The valine to glycine substitution mutation introduced into codon 217 by site directed mutagenesis was left intact. (J:77392)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gata4 Mutation: 36 strains or lines available

References

• Original: J:77392 Crispino JD, et al., Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 2001 Apr 1;15(7):839-44
• All: 1 reference(s)