Cav1^tm1Krc
Targeted Allele Detail

Summary

• Symbol: Cav1^tm1Krc
• Name: caveolin 1, caveolae protein; targeted mutation 1, Kenneth R Chien
• MGI ID: MGI:2386787
• Synonyms: cav-1-
• Gene: Cav1 Location: Chr6:17306387-17341323 bp, + strand Genetic Position: Chr6, 7.73 cM, cytoband A2
• Alliance: Cav1^tm1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78603
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a cassette containing lacZ and neo genes. Transcript was undetected by quantitative RT-PCR of heart and lung tissue obtained from homozygous mutant mice. Neither Western blot analysis nor immunostaining detected protein in homozygous mutant mice. (J:78603)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cav1 Mutation: 31 strains or lines available

References

• Original: J:78603 Zhao YY, et al., Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11375-80
• All: 2 reference(s)