Gopc^tm1.1Tno
Targeted Allele Detail

Summary

• Symbol: Gopc^tm1.1Tno
• Name: golgi associated PDZ and coiled-coil motif containing; targeted mutation 1.1, Tetsuo Noda
• MGI ID: MGI:2386794
• Synonyms: GOPC^-
• Gene: Gopc Location: Chr10:52213120-52258220 bp, - strand Genetic Position: Chr10, 26.54 cM, cytoband B3
• Alliance: Gopc^tm1.1Tno page

Ultrastructural analysis of spermatogenic cells from wild type and Gopc^tm1.1Tno/Gopc^tm1.1Tno mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78599
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was excised from Gopc^tm1Tno by the in vivo expression of cre recombinase. A lacZ gene remained in place of exons 2, 2b, and 3. Neither of the two protein isoforms produced by the endogenous locus were detected in homozygous mutant mice by Western blot and immunohistochemical analyses. (J:78599)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gopc Mutation: 25 strains or lines available

References

• Original: J:78599 Yao R, et al., Lack of acrosome formation in mice lacking a Golgi protein, GOPC. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11211-6
• All: 8 reference(s)