Mttp^tm1Chan
Targeted Allele Detail

Summary

• Symbol: Mttp^tm1Chan
• Name: microsomal triglyceride transfer protein; targeted mutation 1, Lawrence Chan
• MGI ID: MGI:2386838
• Synonyms: lMTP^-
• Gene: Mttp Location: Chr3:137795616-137849179 bp, - strand Genetic Position: Chr3, 64.06 cM
• Alliance: Mttp^tm1Chan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53390
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 5 and 6 were flanked by a single loxP site in intron 4 and a neo cassette with a 3' loxP site in intron 6. Basal plasma cholesterol and triglyceride levels in mutant mice were similar to those in wild-type mice, indicating that the intronic neo cassette did not affect gene expression. (J:53390)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mttp Mutation: 53 strains or lines available

References

• Original: J:53390 Chang BH, et al., Liver-specific inactivation of the abetalipoproteinemia gene completely abrogates very low density lipoprotein/low density lipoprotein production in a viable conditional knockout mouse. J Biol Chem. 1999 Mar 5;274(10):6051-5
• All: 9 reference(s)