Mesp2^tm4Ysa
Targeted Allele Detail

Summary

• Symbol: Mesp2^tm4Ysa
• Name: mesoderm posterior 2; targeted mutation 4, Yumiko Saga
• MGI ID: MGI:2386844
• Synonyms: Mesp2^L, Mesp2-LacZ
• Gene: Mesp2 Location: Chr7:79460475-79463179 bp, + strand Genetic Position: Chr7, 45.18 cM
• Alliance: Mesp2^tm4Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78989
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequences were replaced by a lacZ-PGK-neomycin resistance cassette. This allele expresses beta-galactosidase under the control of the Mesp2 promoter. (J:78989)

Expression

In Mice Carrying this Mutation:

41 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mesp2 Mutation: 30 strains or lines available

References

• Original: J:78989 Takahashi Y, et al., Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat Genet. 2000 Aug;25(4):390-6
• All: 6 reference(s)