Mesp2^{tm5(Notch1)Ysa}
Targeted Allele Detail

Summary

• Symbol: Mesp2^{tm5(Notch1)Ysa}
• Name: mesoderm posterior 2; targeted mutation 5, Yumiko Saga
• MGI ID: MGI:2386850
• Synonyms: Mesp2^N
• Gene: Mesp2 Location: Chr7:79460475-79463179 bp, + strand Genetic Position: Chr7, 45.18 cM
• Alliance: Mesp2^{tm5(Notch1)Ysa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78989
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Constitutively active, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mesp2^{tm5(Notch1)Ysa} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Notch1 (MGI:97363)

• Mutation details: The coding sequences were replaced by an in-frame Notch1 intracellular cDNA sequence followed by a PGK-neomycin resistance cassette. This allele expresses an activated form of NOTCH1 under the control of the Mesp2 promoter. (J:78989)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mesp2 Mutation: 30 strains or lines available

References

• Original: J:78989 Takahashi Y, et al., Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat Genet. 2000 Aug;25(4):390-6
• All: 2 reference(s)