Hic1^tm1Sbb
Targeted Allele Detail

Summary

• Symbol: Hic1^tm1Sbb
• Name: hypermethylated in cancer 1; targeted mutation 1, Stephen B Baylin
• MGI ID: MGI:2386879
• Synonyms: Hic1-
• Gene: Hic1 Location: Chr11:75055391-75060345 bp, - strand Genetic Position: Chr11, 45.76 cM
• Alliance: Hic1^tm1Sbb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60589
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene coding region was deleted and replaced with a lacZ-PGK-neo cassette via homologous recombination. Northern blot analysis of whole embryo total RNA showed an absence of gene expression in homozygous mutants. (J:60589)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hic1^tm1Sbb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hic1 Mutation: 36 strains or lines available

References

• Original: J:60589 Carter MG, et al., Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Hum Mol Genet. 2000 Feb 12;9(3):413-9
• All: 9 reference(s)