Chek2^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Chek2^tm1Mak
• Name: checkpoint kinase 2; targeted mutation 1, Tak Mak
• MGI ID: MGI:2386905
• Synonyms: Chk2^-
• Gene: Chek2 Location: Chr5:110987845-111022011 bp, + strand Genetic Position: Chr5, 53.73 cM, cytoband F
• Alliance: Chek2^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60946
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 through 11 were replaced with a neomycin selection cassette inserted via homologous recombination. Protein was undetected in homozygous mutant mice via Western blot analysis of various tissues. (J:60946, J:78491)

Expression

In Mice Carrying this Mutation:

2 assay results

Tumor Data

List all tumor models in MMHCdb carrying Chek2^tm1Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chek2 Mutation: 54 strains or lines available

References

• Original: J:60946 Hirao A, et al., DNA damage-induced activation of p53 by the checkpoint kinase Chk2 [see comments]. Science. 2000 Mar 10;287(5459):1824-7
• All: 23 reference(s)