Lgals3^tm1Ftl
Targeted Allele Detail

Summary

• Symbol: Lgals3^tm1Ftl
• Name: lectin, galactose binding, soluble 3; targeted mutation 1, Fu-Tong Liu
• MGI ID: MGI:2386938
• Synonyms: gal3^-, Gal-3^-, Lgals3^-
• Gene: Lgals3 Location: Chr14:47611317-47623624 bp, + strand Genetic Position: Chr14, 24.6 cM, cytoband C1
• Alliance: Lgals3^tm1Ftl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60741
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The carbohydrate-binding domain coding region was disrupted by replacing 0.5 kb of genomic sequences at the intron 4-exon 5 junction with a neomycin resistance cassette. Western blot analysis of several organ samples from homozygous mutant mice confirmed the absence of protein expression. (J:60741)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lgals3 Mutation: 29 strains or lines available

References

• Original: J:60741 Hsu DK, et al., Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses. Am J Pathol. 2000 Mar;156(3):1073-83
• All: 89 reference(s)