Ogg1^tm1Tld
Targeted Allele Detail

Summary

• Symbol: Ogg1^tm1Tld
• Name: 8-oxoguanine DNA-glycosylase 1; targeted mutation 1, Tomas Lindahl
• MGI ID: MGI:2386943
• Synonyms: ogg1-
• Gene: Ogg1 Location: Chr6:113303959-113311149 bp, + strand Genetic Position: Chr6, 52.75 cM, cytoband E-F1
• Alliance: Ogg1^tm1Tld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58517
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding the highly conserved helix-hairpin-helix motif required for enzyme activity were replaced by a neomycin selection cassette. (J:58517)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129P2/OlaHsd
cx2	Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129 * C57BL/6J
cx3	Msh2^tm1Mak/Msh2^tm1Mak Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129 * C57BL/6J
cx4	Msh2^tm1Mak/Msh2^+ Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129 * C57BL/6J

Phenotypes:

Affected Systems	hm1	cx2		cx3	cx4
show or hide all annotated terms Sex:
endocrine/exocrine glands		√			√
increased ovary tumor incidence		√			√
mortality/aging		√	√	√	√	√
premature death		√	√	√	√	√
neoplasm		√	√	√	√	√
increased tumor incidence		√	√	√	√	√
increased ovary tumor incidence		√			√
increased hemangioma incidence		√	√
increased lymphoma incidence		√	√	√	√	√
increased lung tumor incidence		√	√
increased lung adenoma incidence		√	√	√	√	√
increased lung adenocarcinoma incidence					√	√
reproductive system		√			√
increased ovary tumor incidence		√			√
respiratory system		√	√	√	√	√
increased lung tumor incidence		√	√
increased lung adenoma incidence		√	√	√	√	√
increased lung adenocarcinoma incidence					√	√
normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ogg1 Mutation: 23 strains or lines available

References

• Original: J:58517 Klungland A, et al., Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5
• All: 41 reference(s)