Ogg1^tm1Tld
Targeted Allele Detail

Summary

• Symbol: Ogg1^tm1Tld
• Name: 8-oxoguanine DNA-glycosylase 1; targeted mutation 1, Tomas Lindahl
• MGI ID: MGI:2386943
• Synonyms: ogg1-
• Gene: Ogg1 Location: Chr6:113303959-113311149 bp, + strand Genetic Position: Chr6, 52.75 cM, cytoband E-F1
• Alliance: Ogg1^tm1Tld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58517
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding the highly conserved helix-hairpin-helix motif required for enzyme activity were replaced by a neomycin selection cassette. (J:58517)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ogg1 Mutation: 23 strains or lines available

References

• Original: J:58517 Klungland A, et al., Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5
• All: 41 reference(s)