Rr320^tm1.1Mkg
Targeted Allele Detail

Summary

• Symbol: Rr320^tm1.1Mkg
• Name: regulatory region 320; targeted mutation 1.1, Mark Groudine
• MGI ID: MGI:2386946
• Synonyms: deltaLCR, Hbb-ar^tm1.1Mkg
• Gene: Rr320 Location: Chr7:103501973-103526752 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Rr320^tm1.1Mkg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60714
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is derived from Rr320^tm1Mgk. The 24 kb region of the gene containing 5' HS sites 1-6 flanked by loxP sites were removed by mating mutant animals to a cre-expressing line. Correct removal of the floxed sequence was confirmed by Southern blot analysis. (J:60714)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr320 Mutation: 0 strains or lines available

References

• Original: J:60714 Bender MA, et al., Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol Cell. 2000 Feb;5(2):387-93
• All: 7 reference(s)