Jag1^Mhdahtu
Chemically induced Allele Detail

Summary

• Symbol: Jag1^Mhdahtu
• Name: jagged 1; Martin Hrabe de Angelis headturner
• MGI ID: MGI:2386949
• Synonyms: ABE2, Gsfabe2, headturner, Htu, Jag1^Htu
• Gene: Jag1 Location: Chr2:136923371-136958440 bp, - strand
• Alliance: Jag1^Mhdahtu page

Inner ear of Jag1^Mhdahtu/Jag1⁺ mice at E16.5 shows missing or smaller ampullae

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Genomic sequence analysis of the coding region revealed a G-to-A missense mutation at coding cDNA nucleotide position 866 (c.866G>A) resulting in a nonconservative amino acid substitution of a glycine by an aspartic acid residue at position 289 of the encoded protein (p.G289D). (J:72108)
• Inheritance: Dominant

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Jag1 Mutation: 78 strains or lines available

References

• Original: J:72108 Kiernan AE, et al., The Notch ligand Jagged1 is required for inner ear sensory development. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3873-8
• All: 6 reference(s)