Ror2^tm1Gdy
Targeted Allele Detail

Summary

• Symbol: Ror2^tm1Gdy
• Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, George D Yancopoulos
• MGI ID: MGI:2386954
• Synonyms: Ror2^-, Ror2^TMlacZ
• Gene: Ror2 Location: Chr13:53263353-53440160 bp, - strand Genetic Position: Chr13, 27.68 cM, cytoband B3
• Alliance: Ror2^tm1Gdy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60754
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the thymidine kinase-like domain with a lacZ-neo cassette resulting in the fusion of the ecto- and transmembrane-domains with lacZ. Beta-gal staining of mutant embryo sections and in situ hybridization analysis confirmed expression of the fusion product is similar to that of the endogenous protein. (J:60754)

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ror2 Mutation: 125 strains or lines available

References

• Original: J:60754 DeChiara TM, et al., Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat Genet. 2000 Mar;24(3):271-4
• All: 6 reference(s)