Traf1^tm1Tsi
Targeted Allele Detail

Summary

• Symbol: Traf1^tm1Tsi
• Name: TNF receptor-associated factor 1; targeted mutation 1, Erdyni Y Tsitsikov
• MGI ID: MGI:2386957
• Synonyms: TRAF1^-
• Gene: Traf1 Location: Chr2:34831762-34851784 bp, - strand Genetic Position: Chr2, 23.13 cM
• Alliance: Traf1^tm1Tsi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72327
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 2-5 with a neomycin resistance cassette. Homozygous mutant animals did not express protein product as determined by Western blot analysis of stimulated splenocytes using polyclonal antibodies directed against the C-terminus of the protein. (J:72327)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Traf1 Mutation: 20 strains or lines available

References

• Original: J:72327 Tsitsikov EN, et al., Traf1 is a negative regulator of tnf signaling. enhanced tnf signaling in traf1-deficient mice. Immunity. 2001 Oct;15(4):647-57
• All: 22 reference(s)