Ucn^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Ucn^tm1Brd
• Name: urocortin; targeted mutation 1, Allan Bradley
• MGI ID: MGI:2386958
• Synonyms: Ucn^-
• Gene: Ucn Location: Chr5:31295407-31296173 bp, - strand Genetic Position: Chr5, 17.11 cM
• Alliance: Ucn^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78595
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains the entire coding region, was replaced by a cassette containing an enhanced GFP-LacZ fusion gene and a floxed PGK-neo gene. In situ hybridization of brain sections showed a lack of transcript in the Edinger-Westphal (EW) nuclei of homozygous mutant mice. Correlatively, expression of beta-galactosidase was observed in the EW nuclei of mutant mice. (J:78595)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucn Mutation: 4 strains or lines available

References

• Original: J:78595 Wang X, et al., Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response. Mol Cell Biol. 2002 Sep;22(18):6605-10
• All: 1 reference(s)