Cenpb^tm1Gmay
Targeted Allele Detail

Summary

• Symbol: Cenpb^tm1Gmay
• Name: centromere protein B; targeted mutation 1, Gregory S May
• MGI ID: MGI:2386968
• Synonyms: Cenp-B -
• Gene: Cenpb Location: Chr2:131019209-131021974 bp, - strand Genetic Position: Chr2, 63.29 cM
• Alliance: Cenpb^tm1Gmay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53053
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 1.7 kb of the gene (from 65 bp upstream of the ATG start codon to 105 bp upstream of the stop codon) was deleted and replaced with a PGK-neo cassette. Absence of gene expression in homozygous mutants was confirmed by Western blot analysis of mouse embryonic fibroblasts (MEFs) derived from E10.5 embryos. (J:53053)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cenpb Mutation: 18 strains or lines available

References

• Original: J:53053 Kapoor M, et al., The cenpB gene is not essential in mice. Chromosoma. 1998 Dec;107(8):570-6
• All: 1 reference(s)