Stk10^tm1Hkar
Targeted Allele Detail

Summary

• Symbol: Stk10^tm1Hkar
• Name: serine/threonine kinase 10; targeted mutation 1, Hajime Karasuyama
• MGI ID: MGI:2386974
• Synonyms: lok^-/-
• Gene: Stk10 Location: Chr11:32483305-32574587 bp, + strand Genetic Position: Chr11, 18.97 cM, cytoband A4
• Alliance: Stk10^tm1Hkar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60738
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Western blot analysis of splenocytes from homozygous mutant animals confirmed the absence of gene expression. (J:60738)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk10 Mutation: 37 strains or lines available

References

• Original: J:60738 Endo J, et al., Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. FEBS Lett. 2000 Feb 25;468(2-3):234-8
• All: 2 reference(s)