Tg(LPV-TAg1135)11Tvd
Transgene Detail

Summary

• Symbol: Tg(LPV-TAg1135)11Tvd
• Name: transgene insertion 11, Terry Van Dyke
• MGI ID: MGI:2386975
• Synonyms: dll35, LST1135, LST1135-11, Tdn/11, Tg(LPV-SV40T)11Tvd, TgLST1135, TgTdeltaN
• Transgene: Tg(LPV-TAg1135)11Tvd Location: unknown
• Alliance: Tg(LPV-TAg1135)11Tvd page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A mutant SV40 T-antigen sequence deleted for amino acids 17-27 and the small t-specific splice donor site was used as the transgene. As a result the large T-antigen should be expressed, but not the small T-antigen. The mutant transgene was fused to the lymphotrophic papovavirus (LPV) enhancer and early promoter to target expression to B- and T-lymphocytes and choroid plexus epithelium. The mutant protein retains the ability to bind RB1, RBL1, and TRP53. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium. Western blot analysis of transgenic animals confirmed expression of the transgene in the thymus and spleen. (J:78681, J:89094)

Tumor Data

List all tumor models in MMHCdb carrying Tg(LPV-TAg1135)11Tvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Seventeen founders generated: 10, 11, 12, 13, 14, 16, 18, 19, 20, 21, 22, 24, 27, 28, 34, 36, and 37. Line 11 continued.

References

• Original: J:78681 Symonds HS, et al., Use of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant. Mol Cell Biol. 1993 Jun;13(6):3255-65
• All: 3 reference(s)