Ngfr^tm1Gdc
Targeted Allele Detail

Summary

• Symbol: Ngfr^tm1Gdc
• Name: nerve growth factor receptor (TNFR superfamily, member 16); targeted mutation 1, Georg Dechant
• MGI ID: MGI:2386981
• Synonyms: p75e4-, p75^exonIV-, p75(IV)^-, p75NTR^exonIV
• Gene: Ngfr Location: Chr11:95459644-95478524 bp, - strand Genetic Position: Chr11, 59.01 cM
• Alliance: Ngfr^tm1Gdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71955
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neo cassette was inserted into exon 4 of the endogenous locus by homologous recombination. Western blot analysis confirmed the absence of both known isoforms, to which exon 4 is common. (J:71955)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ngfr Mutation: 33 strains or lines available

References

• Original: J:71955 von Schack D, et al., Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat Neurosci. 2001 Oct;4(10):977-8
• All: 19 reference(s)