Il6st^tm1Thir
Targeted Allele Detail

Summary

• Symbol: Il6st^tm1Thir
• Name: interleukin 6 signal transducer; targeted mutation 1, Toshio Hirano
• MGI ID: MGI:2386991
• Synonyms: F759, gp130^F759
• Gene: Il6st Location: Chr13:112600604-112643394 bp, + strand Genetic Position: Chr13, 63.73 cM
• Alliance: Il6st^tm1Thir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: A human Il6st cDNA fragment carrying a tyrosine to phenylalanine substitution at position 759 (Y759F), was used to replaced the corresponding region of the mouse gene. A downstream neomycin resistance cassette was also inserted for positive selection. The expression level of the mutant protein in B- and T-cells is similar to that of wild-type as determined by flow cytometry. (J:59922)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il6st Mutation: 80 strains or lines available

References

• Original: J:59922 Ohtani T, et al., Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000 Jan;12(1):95-105
• All: 21 reference(s)