Stk11^tm1Tpm
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1Tpm
• Name: serine/threonine kinase 11; targeted mutation 1, Tomi P Makela
• MGI ID: MGI:2387003
• Synonyms: Lkb1^-
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1Tpm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70892
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2 through 7 were replaced with a neomycin selection cassette by homologous recombination. (J:70892)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk11^tm1Tpm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 35 strains or lines available

References

• Original: J:70892 Ylikorkala A, et al., Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 2001 Aug 17;293(5533):1323-6
• All: 9 reference(s)