Gclc^tm1Mwl
Targeted Allele Detail

Summary

• Symbol: Gclc^tm1Mwl
• Name: glutamate-cysteine ligase, catalytic subunit; targeted mutation 1, Michael W Lieberman
• MGI ID: MGI:2387010
• Synonyms: gammaGCS-HS^tm1
• Gene: Gclc Location: Chr9:77661817-77701767 bp, + strand Genetic Position: Chr9, 43.36 cM, cytoband D-E
• Alliance: Gclc^tm1Mwl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62177
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.3 kb region of the gene containing the TATA box and exon 1 was replaced with a PGK-Hprt cassette via homologous recombination. (J:62177)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gclc Mutation: 20 strains or lines available

References

• Original: J:62177 Shi ZZ, et al., Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5101-6
• All: 3 reference(s)